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欧盟评估大孢子黑曲霉变种菌株PTG8398生产的曲霉蛋白酶Ⅰ和 Ⅱ的安全性

放大字体  缩小字体 时间:2022-08-12 09:34 来源:食品伙伴网 作者: 泽夕   
核心提示:2022年8月11日,欧盟食品安全局就一种曲霉蛋白酶Ⅰ和 Ⅱ(aspergillopepsin I and II)的安全性评价发布意见。
   食品伙伴网讯  2022年8月11日,欧盟食品安全局就一种曲霉蛋白酶Ⅰ和 Ⅱ(aspergillopepsin I and II)的安全性评价发布意见。
 
  据了解,这种食品酶是由大孢子黑曲霉变种菌株PTG8398生产的,旨在用于葡萄酒的生产加工。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏和诱发反应的风险,但这种情况发生的可能性很低。根据所提供的数据,评估小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme with aspergillopepsin I (EC 3.4.23.18) and aspergillopepsin II (EC 3.4.23.19) activities is produced with a non-genetically modified Aspergillus niger var. macrosporus strain PTG8398 by Meiji Seika Pharma Co., Ltd. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in wine production. based on the maximum use levels, dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 0.14 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 919 mg TOS/kg bw per day, the highest dose tested which, when compared with the estimated dietary exposure, results in a margin of exposure above 6,700. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and four matches with respiratory allergens were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
 
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日期:2022-08-12
 
 地区: 国外 欧盟
 行业: 食品检测 进出口
 标签: 黑曲霉 欧盟食品安全局 蛋白酶
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