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放大字体  缩小字体 时间:2022-08-23 09:50 来源:食品伙伴网 作者: 泽夕   
核心提示:2022年8月22日,欧盟食品安全局就一种甘露聚糖内切-1,4-β-甘露糖苷酶(mannan endo-1,4-β-mannosidase)的安全性评价发布意见。
   食品伙伴网讯  2022年8月22日,欧盟食品安全局就一种甘露聚糖内切-1,4-β-甘露糖苷酶(mannan endo-1,4-β-mannosidase)的安全性评价发布意见。
  The food enzyme mannan endo-1,4-β-mannosidase (1,4-β-d-mannan mannanohydrolase; EC is produced with the genetically modified Trichoderma reesei strain RF6232 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and recombinant DNA. It is intended to be used in coffee processing, fruit and vegetable processing for juice production and for edible oil production. Since residual amounts of total organic solids (TOS) are removed during refined edible oil production by repeated washing, dietary exposure was calculated only for the remaining two food manufacturing processes. Dietary exposure to the food enzyme–TOS was estimated to be up to 0.09 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 100 mg TOS/kg bw per day, the lowest dose tested. This results in a margin of exposure above 1,100. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and one match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, in particular for individuals allergic to avocado, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 地区: 国外 欧盟
 行业: 食品检测 进出口
 标签: 糖苷 欧盟食品安全局
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